The interaction between the dietary inflammatory index and MC4R gene variants on cardiovascular risk factors

Background Previous studies have shown that the minor allele (C allele) for melanocortin 4 receptor (MC4R) rs17782313, may be associated with incidence of obesity and risk cardiovascular diseases (CVDs). Moreover, inflammation caused by diet has been to have, potentially, unfavorable effects on CVD risk. This study used a linear regression model investigate interactions between dietary inflammatory index (DII) MC4R gene variants markers CVD. Methods comparative cross-sectional was conducted 266 Iranian women overweight obesity. A food frequency questionnaire (FFQ) 147 items assess intakes. Individuals were categorized into three groups based rs17782313 genotype. Participants also divided four DII score. Results Higher quartiles lower levels high density lipoproteins (HDL) (p = 0.01) higher triglycerides (TG) 0.04). There significant difference genotypes insulin < 0.001), HOMA total body mineral content 0.03), bone (BMC) Our findings showed score polymorphism cholesterol, content, BMC, soft lean mass (SLM), fat free (FFM) skeletal muscle (SMM), basal metabolic rate (BMR). Conclusion scores HDL TG levels, respectively; whilst differences observed index, BMC. These results highlight compositions, variants, their interaction, should considered in assessment.